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Presumably those cells in the population that are already in mitosis upon nocodazole addition experience an extended arrest during which Ipl1 is continually recruited.
We initially addressed two questions: do we also see an extended arrest, and if so, is this arrest attributable to the SAC? Greater than 90% of Mlh1−/− oocytes arrested in meiosis I (n = 26), even when coinjected with wild-type Cdc20 mRNA (n = 20).
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(If all this, meanwhile, seems like an extended critical metaphor of the perils of resurrecting and extending "Arrested Development," then, well, maybe so).
Lozman argues, however, that Hartman cannot be extended to arrest cases because arrest cases do not share the causation concerns that motivated Hartman.
Previous use of the same model of extended cardiac arrest (12 min of untreated cardiac arrest (CA) and 8 min of cardiopulmonary resuscitation (CPR) has already been described [ 19].
The static analysis of mitosis thus far indicates that many cells in the esco2 m/m embryos undergo a mitotic arrest with a scattered chromosome phenotype and suggests that this extended mitotic arrest leads to cell death during mitosis.
These events together lead to extended mitotic arrest, ultimately followed by slippage out of mitosis to generate multinucleate proliferation-arrested senescent cells.
The spindle checkpoint causes extended mitotic arrest.
Extended mitotic arrest eventually leads to cell death [ 8].
Live cell imaging of individual mitoses revealed that activated Ras extended mitotic arrest and delayed death in mitosis under DME.
Extended G0/G1 arrest is one way of evading toxicity of cytostatic drugs, since their mode of action is by disturbing cell division [ 32].
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