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In order to estimate the wider lifetime impact of FFR, economic modelling would generally extend trial outcomes.
Data available from specialist Registries may be used to help develop new protocols and to verify and extend trial results.
Low information size also precludes a strong method to extend trial outcomes to a lifetime using the observed data.
The EXTEND trial 25 was a placebo-controlled endoscopy trial that evaluated the effects of adalimumab on mucosal healing in 129 patients with CD involving the colon.
The EXTEND trial revealed improved mucosal healing of gastrointestinal tissue under anti-TNF-α therapy [ 24], despite this it is still unclear whether anti-TNF-α treatment affects the oral mucosa and/or interferes with bone physiology, bone turnover, local immunity and wound repair on the long run.
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In practice, it is very difficult or impossible to extend trials as conducted during the last 15 years to a large number of patients.
Yet China, South Korea and Japan are moving in the opposite direction, introducing or extending trial by jury in a bid to increase the impartiality and independence of their legal systems.
"He's been with us since the summer and has done enough to earn a short-term deal, which is effectively an extended trial," said manager Martin Ling.
Banks have made underwhelming progress on helping struggling mortgage borrowers, extending trial loan modifications to just 9% of those eligible under a $75 billion Obama administration program--and even that number may be inflated.
It considered loan modifications six times in 2007 and extended trial offers twice, she said, but never received the required paperwork.
In his book, Bailout, Barofsky shows how HAMP's faulty design led to a myriad of problems: trapped borrowers, extended trial payments, no-doc modifications, and eventually unnecessary foreclosures.
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