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In our search for compounds able not only to extend the effects of dopamine by preventing its degradation but also to halt or slow the neurodegenerative process, we designed, synthesized, and biologically tested a series of propargylamines for their potential use as therapeutic agents for PD.
While overwinter dormancy is an important determinant of survival, dormancy over multiple seasons has the greatest potential to extend the effects of an isolated hybridization event.
Our observations of the effects of slipped-DNA junction structural dynamics on repair outcomes (protective vs mutagenic) further extend the effects of base base mismatch structural variations.
The Video Presentation element as an intervention in this project was developed with this view to extend the effects of weekly music therapy into the staff day-to-day practice.
Even low persistence of hybrid seed in the soil seed bank, for example, may extend the effects of an initial hybridization event, allowing for the continued emergence of hybrids (e.g. F1 or backcross) in future years (Snow et al. 1998; Mercer et al. 2007).
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Therefore, medical treatment could further extend the effect of AD on tumour proliferation and PET imaging.
It would also be motivating to explore new means to extend the effect of topical anesthetics in relieving pain and discomfort experienced after a couple of hours or even a day from the placement of orthodontic elastomeric separators.
Therefore, complement inflammatory, chemotactic, opsonic and lytic activities extend the effect of the innate arm of immune responses to the core of major hematopoietic organs.
To the best of our knowledge, this is the first clinical study to extend the effect of EA in neuroplasticity markers indexed by the BDNF.
It is quite conceivable that the reduced metabolic rate may extend the effect of the drugs, but we find it unlikely that it would increase the sensitivity of the animals.
Increasing evidence suggests that targeting the Ang-2/Tie-2 signaling pathway to inhibit the function of Tie-2 expressing macrophages might extend the effect of vascular-targeting therapies in cancer patients [ 24].
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