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However, studies of Gene × Environment × Epigenetics further extend the complexity of the experimental designs and create a challenge for selecting the most informative epigenetic readouts that can be feasibly performed to interrogate multiple individuals, exposures, tissue types and toxicity phenotypes.
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Age-related multi-morbidity further increases the contacts with different disciplines and extends the complexity of interactions, often leading to the fragmentation of healthcare services [ 5, 6].
It therefore extends the complexity of GPCR-signalling, despite the fact that future work will have to proof whether pre-assembled complexes represent a widespread phenomenon.
Importantly, UV hypersensitivity resulting from BRG1 inactivation depends on the presence of the checkpoint protein TP53 [ 58], extending the complexity of the involvement of BRG1 in UV-induced DDR.
In addition, lysines can be mono-, di-, or tri-methylated, whereas arginines can be mono- or di-methylated (symmetrically or asymmetrically), thus greatly extending the complexity of histone modification-dependent gene regulation.
Most human genes contain multiple alternative splice sites believed to extend the complexity and diversity of the proteome.
As above using an in vitro model of chicken response to endotoxin, our data revealed the kinetics of gene networks involved in host response to endotoxin and extend the known complexity of networks in chicken immune response to Gram-negative bacteria such as Salmonella.
This makes it possible to extend computation beyond the complexity of multiplication, and to argue about the results.
This unique work will extend the influence of complexity and system science to a much wider audience than has been possible to date.
In this paper, the response function method (RFM) is extended to deal with the complexity of FRF and modal data using complex updating parameters.
Consequently, the results reported here extend the engineering of chemical complexity to a previously uncharted area in materials science of particular relevance to photonic applications.
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