Sentence examples for extend the circulation from inspiring English sources
Herein, we genetically fused an albumin-binding domain (ABD) to the human epidermal growth factor receptor 2 (HER2 -specific immunotoxin ZHER2 -specificxtend the cimmunotoxintime and thus improve the therapeutic outcome of this immunotoxin.
Incorporation of 5 mol% poly ethylene glycol -conjugated lipids (PEglycol -conjugated shown to extend the circulipids longevity of neutral liposomes due to steric repulsion of PEG at thasmembeene shownce.
A well-established strategy to extend the circulation times of these particles is to use ultrasmall SPIOs (USPIOs).
Such modifications shield the nanoplex surface to prevent protein binding, reduce reticuloendothelial uptake, and/or extend the circulation time in vivo.
Nevertheless, the paradigms that have been exploited for nanoparticles and nanoformulations over the past few decades are potentially applicable to extend the circulation time of these LMW compounds.
(28) To extend the circulation half-life of GLP-1, several chemical modification schemes have been proposed, including PEGylation, biotinylation, amino acid substitution, 33) and N-terminal acetylation.
Although often engineered to overcome the numerous barriers that exist in the systemic circulation, many nanocarriers fail in extending the circulation time of the siRNA.
The close PEG membrane wrapping not only guarantees the efficient intracellular photocleavage, but also extends the circulation time and protects the loaded cargos from leakage and degradation.
This type of surface modification shows increased intrinsic anticoagulant and anti-complement properties, as well as other biological activities; in addition, it extends the circulation half-life and reduces the immunogenicity of NPs in the human body.
In comparison to NPs treated with PEG or WSC alone, the synergistic action of PEG and WSC strongly inhibited the macrophage uptake and extended the circulation half-life (t1/2) with concomitant reduced liver sequestration.
Figure 2a indicates that the velocity distribution in PPG formed a large circulation in the bioreactor, which flowed from the bottom to the top (When the shrinking wall extended, the circulation ran reversely).
