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It will also extend the alignment of the seed till the score cut-off and expected cut-off are not met.
It is more likely to find sufficient seeds from which to extend the alignment for longer reads.
BLAST uses identical seeds that might not work well for (short) query sequences that contain mismatches because there might be no seed sequence from which to extend the alignment.
Additional rhesus HSPs were used to extend the alignment region upstream and downstream from the initial alignment until all HSPs were used.
If a two hit is found, the algorithm tries to extend the alignment without gaps, resulting in a high-scoring segment pair (HSP).
As the local algorithm of BLAST does not extend the alignment to include terminal mismatches (e.g., U C), proteins ending with an Sec can escape identification by the standard search methods.
Similar(49)
To ensure full comparability with earlier work, no attempt was made to extend the alignments using more up to date sequence data banks.
Then HubAlign aligns topologically important proteins first and gradually extends the alignment to the whole network.
HUBALIGN (Hashemifar and Xu, 2014) uses a minimum-degree heuristic to align 'important' proteins first and then gradually extends the alignment to the whole networks.
In this work, we describe the multi-conformer PubChem "Similar Conformers" 3-D neighboring relationship and explain various strategies and approaches that made it a tractable problem, including extending the "alignment recycling" methodology to cover the full range of chemical structures considered in the PubChem3D project.
An alignment path is calculated as the optimal path through the similarity matrix by linearly progressing through the sequences and extending the alignment with the next possible high-scoring AFP pair.
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