But the main goal of the trial was to extend survival.
Thus, depleting p62 is sufficient to activate impaired autophagy in lkb1 mutants and extend survival.
A lower dose mitigated these adverse phenotypes but failed to extend survival of Mecp2−/y mice.
New therapies potentially extend survival, but their value is questioned when benefits are incremental and expensive.
Genentech, the biotechnology company, said yesterday that its experimental cancer drug Avastin had failed to extend survival rates significantly in a small trial of patients with colorectal cancer.
Even so, oncologists might have felt bound to use Bexxar and Zevalin if the drugs had been proven to extend survival over older treatments, Dr. Connors said.
He has repeatedly criticized the agency for approving cancer drugs that extend survival by just a few months, and he thinks Republican pressure will just make things worse.
AA has recently been proved to extend survival for men with metastatic castration-resistant prostate cancer who have progressive disease after first-line chemotherapy treatment.
Lung transplantation (LTx) aims to reduce physical disability and mental distress, extend survival, and improve health-related quality of life (HRQoL).
NSCs engineered with a wide array of cytotoxic agents have been found to significantly reduce tumor volumes and markedly extend survival in preclinical models.
Photodynamic therapy (PDT) appears to be an interesting modality to fill the need for a targeted treatment that may reduce recurrence and extend survival with minimal side effects.
