When a very large number of individuals with exome sequence data and whole genome genotypes is available, statistical imputation can also provide an effective strategy for extending sample sizes (97, 98).
Final results are statistically limited and will benefit from future clinical studies to extend the sample size.
The company also claimed that the auditors based their findings on a sample of documents and did not seek to extend the sample size.
In this paper, we extend the sample size formula to scenarios where K (≥3) treatments are compared simultaneously to detect time-averaged differences in treatment effect.
In this study we extend the sample size of prior studies in birds for cox1 (2776 sequences, 756 species) and target especially species that are known to occur parapatrically, and/or are known to hybridise, on a Holarctic scale.
A subsequent study from the same group extended the sample size to 78 breast cancers (including 40 from the original publication) using hierarchical clustering with an intrinsic gene set of 456 cDNA clones.
We have extended our sample size with 5 participants per condition in order to take normal distribution of the data as well as possible post hoc tests into account.
We extended our sample size by using the subset of samples common between the qPCR and SNP datasets, 747 cases and 727 controls, to train a k-nearest neighbour (knn) classifier to predict KIR3DL1/3DS1 copy number using the R and θ signals from ImmunoChip SNPs.
The last two values are indicators of fertility of the older and younger generations, computed as national average values from the surveys analyzed here and shown in Appendix A. Individual-level data from the sources described previously considerably extend the sample sizes, availability of covariates, and range of countries for which data are available.
If the follow-up time will be extended the required sample size will be reduced.
