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The documents retrieved by PathText 2 can help curators to maintain the textual evidence for reactions and to extend pathways by finding related reactions from the documents.
For this reason they have been proposed to extend pathways (Glaab et al., 2010) but they have the main limitation of a lack of directionality.
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The green paper proposes extending Pathways to Work to cover the whole of the Britain by 2008, with an investment of £360m from the government and delivery coming primarily from the private and voluntary sectors.
Extending pathways into SuperPaths affords two major advantages.
These extended pathways also involve the mammillary bodies, the retrosplenial cortex and parts of the prefrontal cortex.
We developed a method for constructing extended pathways that start at the receptor level and via a complex intracellular signalling pathway identify those mechanisms that drive cellular behaviour.
Using the two datasets, we construct "extended" pathways that integrate intracellular activity with cellular responses using a hybrid logical/data-driven computational approach.
Here we presented a method for constructing extended pathways that start at the receptor level and via a complex intracellular signalling pathway identify those mechanisms that drive cellular response.
As a case study, we construct extended pathways for studying hepatocellular carcinoma (HCC), a liver cancer disease that is the third leading cause of cancer death with inadequate therapeutic interventions [ 28, 29].
The nuclear hormone receptor NHR-80 (homologmolog) has recently been shown to be required specifically for longevity in germline less animals but not for other life extending pathways such as IIS and dietary restriction (Goudeau et al., 2011).
As a first step in identifying ad-ditional downstream genes associated with DR life span extending pathways we examined which of the 19 re-maining upregulated genes are also upregulated in long-lived takeout expressing flies using qPCR on- mRNA from the flies overexpressing takeout in adult neurons.
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