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Determining orthologous gene groups, where at least one member has a known function, is a common method to extend functional annotation to genes in other species [ 1, 2].
By taking advantages of these genome editing systems, we are now able to extend functional mechanistic studies to more research fields.
Morphological analyses show that Pten deletion from embryonic dopamine neurons enhances the overall reinnervation of the dopamine depleted striatum after grafting and leads to a markedly increased capacity for neurons to extend functional axons into areas distal from the graft placement site.
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ToxAlert [38] extended functional groups (EFG) [39] included 583 groups covering different functional features of molecules.
On the other hand we find a class C of functions in two real variables and construct a functional calculus on this class which extends functional calculi constructed earlier.
John von Neumann, working with Oskar Morgenstern on the theory of games, broke new mathematical ground in 1944 by extending functional analytic methods related to convex sets and topological fixed-point theory to economic analysis.
Based on this phylogeny, association of yet uncharacterized kinases to families was possible which extended functional annotation of unknowns.
Here, the binding site rules were defined by extending functional groups that are occupied in every reaction rule.
As hypothesized, the (extended) functional DMN broke down into separate anterior and posterior parts in TLE, corroborating previous studies.
Future detailed and extended functional analyses should be conducted to elucidate their role in the development of these evolutionary important traits in cichlid fishes.
Further, transcriptome information from 30 developmental stages (Graveley et al. 2011), and extended functional annotation and mutant phenotypic information are currently available allowing for a more refined characterization.
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