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It has to be considered though, that to some extend, effects might be hidden under the experimental error.
- However, it is not completely understood, to what extend effects of 1,25(on)2D on apoptosis, IL-6, PARP, JNK or MAPK are responsible for this protective effect.
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These extended effects have implications for climate change, resource consumption, and environmental and human health, which may be meaningful topics for many stakeholders not currently considered.
Sirt1 is an NAD-dependent deacetylase which is considered to be important for the lifespan extending effects of CR.
The life span extending effects of DN-Dmp53 are furthermore smaller than the life span extending effects of CR.
We propose a model for the life span extending effects of CR in flies.
Will it help to analyze extended effects of the intervention by record data at 6 months?
In these studies lifespan extending effects were mostly confined to females, unlike the results presented here.
We have previously demonstrated that the life span extending effects of CR are partially mediated by dSir2 [ 7].
For instance, odours from yeast have been shown to modulate the longevity extending effects of dietary restriction [ 9].
Taken together, our data demonstrate that Dmp53 is a down stream target of dSir2 enzymatic activity and mediates some aspects of the life span extending effects of CR.
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