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The method also provides the basis to extend diagnostic capabilities of the network to a measure of the background electron density (Ponomarenko et al. 2011b).
In the future, applying this technique and elaborating more elaborated scoring procedures together with additional IF markers may extend diagnostic options leading to a fast and reliable characterization of tumor properties in individual patients.
As such, this assay may be a useful complementary test to perform in conjunction with current ACPA or RF assays, not only to extend diagnostic accuracy, but also to assist in detecting RA in cases that are either ACPA or RF negative.
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If typical risk factors are not apparent, it may be prudent to extend diagnostics for exclusion of underlying diseases and precedent infections.
The proposed approach was thoroughly tested and then applied to Hokkaido East data allowing for the physically justified estimation of the elevation, which considerably extends diagnostic capabilities of the network.
Similar approaches using extended diagnostic criteria have been used in both epidemiological and genetic studies of anxiety disorders [63] [65].
Five of 12 individuals meeting both extended diagnostic testing criteria had HNF1A or HNF4A mutations (41.6%).
Almost 70% of the network clinics had on-site access to extended diagnostic services.
Our restricted sample size is exemplified by some fluctuation in p values in the analyses of core and extended diagnostic groups (e.g., rs7719346 and rs4880179).
Expert advice should be sought and calves submitted for extended diagnostic investigation where surveillance programs for genetic diseases are in place.
In addition, we broadened our definition of anxiety disorder subjects to include individuals with sub-threshold diagnoses as defined by the CIDI (extended diagnostic group).
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