One such tool to embody this approach is Pagan [ 14], a phylogeny-aware multiple sequence alignment method capable of extending a reference alignment by placing a query sequence into its correct phylogenetic context.
The techniques used above for a direct comparison experimental design were extended to a reference sample design (see Methods).
The MetaboLights repository is being extended with a reference layer/knowledge base of curated quality data about metabolites (1), scheduled to launch in Summer 2013.
A stereotype is a specific metaclass that can be used to extend an element of the reference metamodel.
Similarly, our method can be easily extended to form a reference panel by incorporating sequences partly from the study sample and partly from an external database such as the HapMap Project or the 1000 Genomes Project.
Albert refuses to extend the reference of physical terms to supernatural, purely imaginary possibilities.
Therefore, there is no reason to extend the reference period to be more than around 40 43 years.
Furthermore, there is a trade-off in the selection of the lens focal length, as short focal lengths are more prone to optical aberrations, while long focal lengths can significantly and inconveniently extend the reference delay.
Obviously, we needed such a procedure because there is no gold standard for gut feelings in general practice and we wanted to extend our reference beyond the agreement of the 5 family physicians who were part of the project group.
To handle SNPs during alignment, we extend the reference genome alphabet from the 4-letter A/C/T/G nucleotide code to the 16-letter IUPAC nucleotide code (Cornish-Bowden, 1985).
