Exact(2)
We draw on research in accounting, economics, psychology, and neuroscience to critique the accountabilities, incentives, and learning opportunities embedded in auditors' extant regulatory environment.
In simulated settings, we show that these parsimonious histories can be used to accurately reconstruct a common ancestral regulatory network of two extant regulatory networks.
Similar(58)
Second, selection against extant cis-regulatory alleles is rather weak, we would not expect to observe a set of genes that have invariant cis-regulation across numerous yeast strains.
Similarly, estimates of the strength of selection acting on extant cis-regulatory polymorphisms would be diluted by the presence of neutral polymorphisms in promoters and 3′ untranslated regions (Ronald and Akey 2007).
The legal responsibilities of businesses imply that these entities must fulfil their economic mission within the extant framework of rules and regulatory parameters.
The substrate-binding and regulatory properties of extant ELKs are due to co-evolution of additional insert regions with core domain variations.
The basic idea of network motifs was that a number of regulatory patterns appeared in extant networks much more often than in randomized ones [4], [22].
For example, our analysis assumes that regulatory interactions in the extant E. coli genome reflect interactions at the time of duplication.
Although many gaps exist in our knowledge on the mechanisms of imprinting on SDHD, balancing selection on SDHA and transcript mutations in SDHB, including their impact on SDH enzyme activity, the extant data on PGL suggest that these regulatory mechanisms might downregulate SDH function and facilitate early detection of and pre-adaptation to hypoxia (Figure 4).
The functional assays reveal that these Hox response cis-elements are recognized by the regulatory components of different and extant species.
In analogy with ancestral genome reconstruction [ 1], we consider the problem of predicting the topology of the common ancestor of pathways, complexes, or regulatory programs present in multiple extant species.
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