First, to quantify whether a complex is embedded within a highly-connected region of the PPI network, we derive EXT, the number of external proteins that are highly connected to it, defined as being connected to at least half of the proteins in the complex.
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Ext, meniscal extrusion; n, number of participants; MRI, magnetic resonance imaging; BML, bone marrow lesions.
Ext, meniscal extrusion; n, number of participants; WOMAC, Western Ontario and McMaster Universities Osteoarthritis Index (each subscale, 100 = worst score; total scale, 300 = worst score).
Ext, meniscal extrusion; n, number of participants; BML, bone marrow lesions; WOMAC, Western Ontario and McMaster Universities Osteoarthritis Index (each subscale, 100 = worst score; total scale, 300 = worst score); VAS, visual analog scale (0 mm = no pain, 100 mm = most severe pain); MRI, magnetic resonance imaging.
Ext, meniscal extrusion; n, number of participants; WOMAC, Western Ontario and McMaster Universities Osteoarthritis Index (each subscale, 100 = worst score; total scale, 300 = worst score); VAS, visual analog scale (0 mm = no pain, 100 mm = most severe pain); BML, bone marrow lesions MRI, magnetic resonance imaging.
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If we denote by η ext and ν ext the number of external homoclinic and heteroclinic solutions respectively, it holds that 0 ≤ η ext − ν ext ≤ 1.
