Sentence examples for exquisite selectivity of from inspiring English sources

Instead, we suggest that what appears as the exquisite selectivity of the third domain towards natural ligands may simply reflect the selective pressures imposed by evolution on functional organization of the postsynaptic density, which led to a relatively limited number of the PDZ3 ligands encoded in the genome.

The exquisite selectivity of naturally-occurring enzymes therefore makes it possible that the enzyme-cleavable group could be rationally designed and tailored for each enzyme of interest, thus making an analytical toolkit of diagnostic probes for detecting enzymes which are over-expressed in disease.

Since the exquisite selectivity of K+ channels for K+ has been shown to depend on 'selectivity sequence' TT V/I GYG as well as a number of other stabilizing interactions involving other P-loop residues it has been suggested that the selectivity properties of HCN channels arise from differences these P-loop regions [1], [13], [14].

In the absence of Kaps, even signal-specific cargoes that are smaller entities than entire Kap cargo complexes are rejected, which demonstrates the exquisite selectivity of the NPC.

The purification and study of F-ATPases from mitochondria has been aided greatly by the development of a simple affinity chromatography method that exploits the exquisite selectivity of the natural inhibitor protein IF1 for mitochondrial F-ATPases [ 28].

The exquisite selectivity of trabectedin against mononuclear phagocytes (monocytes and macrophages) was recently related to the rapid activation of caspase 8 by membrane signalling TRAIL receptors; these receptors are expressed more in monocytes/macrophages than in neutrophils and lymphocytes (Germano et al, 2013).

Different E2 E3 pairs degrade different proteins; the specificity of E3s for certain groups of proteins provides exquisite selectivity to this degradation.

In addition, its unique receptor binding specificity with exquisite selectivity for human glycans provides an explanation for the mechanisms of host specificity of the Salmonella enterica serovars that cause typhoid fever.

Remarkably, no binding was observed with the non-phosphorylated versions of the MELT2 and MELT4 peptides, indicating exquisite selectivity for the phosphorylated MELT motifs.

The strategy afforded exquisite selectivity for Hg2+ against other metal ions in real environmental samples.

Our strategy afforded exquisite selectivity for Hg2+ against other environmentally related metal ions.