On the other hand, numerous studies have shown that codon bias is generally positively correlated with gene expression wherein the bias is usually high in highly expressed genes (Andersson and Kurland 1990; Rocha 2004; Behura et al. 2010; Behura and Severson 2011; Botzman and Margalit 2011).
Over the years, as his cinema became more cerebral, his style grew starker and more subdued, moving away from what he called "a distracting expression wherein shots succeed each other ceaselessly".
Our data with JNK2 align with the paradoxial effects of oncogene expression wherein oncogene expression often faciliates cell replication but under certain conditions it ultimately induces a response that is incompatible with cell cycle transit.
Lamszuz et al (2000) noted a strong correlation between meningioma histological grade and VEGF expression, wherein increased VEGF expression was linked to higher WHO grades.
We confirmed our observation experimentally through hsa-miR29b expression, wherein expression of hsa-miR29b could block the expression of MDM2 both at the transcript level and protein level (Fig. 4).
In addition, our finding that Bmp4 expression is disrupted in Megf8 −/− embryos at the site of defasciculation of the TG ophthalmic branch suggests a possible non-cell autonomous role for Megf8 in regulating Bmp4 expression, wherein BMP4 expression is dependent on signaling from incoming TG axons, which is disrupted by defasciculation in the Megf8 −/− embryo.
The reduction in eIF1 abundance implies that the rps5 mutations overcome the autoregulation of eIF1 expression, wherein low eIF1 levels suppress the effect of poor context at the SUI1 AUG codon to boost eIF1 abundance (Ivanov et al., 2010; Martin-Marcos et al., 2011).
A reporter plasmid, pAdCMV5-CuO-GFP, containing a GFP expression cassette wherein GFP expression is regulated by the CMV5-CuO promoter, was stably expressed in 293CymR clone 21 to generate 293CymR-CMV5-CuO-GFP 293CymR-CMV5-CuO-GFP 293CymR-CMV5-CuO-GFP 293CymR-CMV5-CuO-GFP
Only 2 7% of these pairs included paralogs that both had a unique expression profile wherein one paralog is expressed at a developmental stage or a tissue type where the other one is not expressed, and vice versa (Fig. 3).
The two PCR fragments were cloned into pAdCMV5-K7-BFP [ 41] in a three-way ligation to create an expression vector wherein the CMV5 promoter was driving the expression of the chimaeric protein, CymR-VP16 (pAdCMV5-cTA-K7BFP).
In sharp contrast to the healthy pattern of expression that restricts MUC1 to luminal surfaces, cancerous tissues display an aberrant expression pattern wherein MUC1 is uniformly distributed over the entire tissue surface [6], [7].
