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Defining these patterns have largely depended on the expertise of the researchers, for example, Gerber et al defined six temporal expressions trends in terms of phase (early, middle and late) and direction (increase and decrease) [ 31], similarly, Wu et al. proposed 27 possible temporal patterns to group gene expression data for CD8 T cell differentiation [ 34].
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Here we identified five different PAL transcripts differentially expressed presenting different expression trends.
The proper formulation for the interaction between the metabolism and gene expression by applying the principle of growth optimization enables the accurate prediction of multi-scale phenotypes [25], where constitutively expressed genes show growth-rate-dependent expression trends [57,58].
RT-qPCR was used to validate the expression trends of selected genes identified as being differentially expressed by microarray analysis.
These different expression trends of miRNAs suggest a dynamic expression profile of miRNAs in distinct organs.
This study is the first to show gene expression trends of this nature.
First, for each gene we identify expression trends that occur frequently across multiple datasets.
Table 1 The proteins specifically encoded by 1Sl genome and their expression trends under drought stress Spot ID Accession no.
Further analysis of the heatmap showed eight different expression trends of miRNAs in these three organs (Fig. 1B I).
When evaluating the gene expression trends observed in the macrophages, there was a highly significant increase in TNF-α expression for the 50-nm topography.
Based on the expression profile of miRNAs, the hierarchy cluster analysis was applied and eight different expression trends were labeled as C1 to C8. (B I) The eight expression trends (C1 to C8) as indicated in (A) were plotted with the expression values of individual miRNAs.
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