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In particular, multiple lines of evidence indicate the expressions of module 83 are controlled by TGFβ pathway activities.
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The profile of the SRF transcription factor appears to correlate poorly with the expression of module 29 genes in our dataset (Data file S1), explaining why this gene could not be selected as a regulator.
In the former, high expression of module genes is detected primarily in highly dividing tissues.
Here, we report comprehensive identification of coexpression gene modules of tomato (Solanum lycopersicum) and experimental verification of coordinated expression of module member genes.
We then experimentally verified the coordinated expression of module member genes using tomato plants overexpressing a non-enzymatic module member gene that is a strong candidate for a regulatory gene in flavonoid biosynthesis.
The results are summarized in Fig. 2 which shows the t-test p-values of differential expression of module eigengenes in the various brain regions from which samples were taken.
We calculated the expression of modules in different level in terms of cell cycles (or approximately reprogramming days).
Modules J and K exhibited such patterns regardless of the dietary conditions, whereas the expression of Modules L, M, and N showed such patterns only when insects were fed on soybean diets.
We defined the total expression of all modules in Kth level at time t as the portion of living cells arrived at state k at time t: (3) The gene expression of modules in level 1 decreases dramatically at the beginning of the reprogramming, as the reprogramming factors inhibit the expression of somatic genes.
Like for module 29 and SRF, the expression profile of TCF12 is highly divergent from the expression profiles of module 18 genes, explaining why this gene was not selected as module gene or regulator (data not shown).
Expression profile of Module Eigengenes.
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