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Tet also greatly reduced the activation and expressions of matrix degrading enzymes MMP-2/9, the expression of F-actin and the activation of FAK, which controlled the morphologic changes in migration process of FLS.
Elevated expressions of matrix metalloproteinases (MMPs) are associated with increased metastatic potential in many tumor cells [35], [36], [37].
Among invasion candidate genes, expressions of matrix metalloproteinase (MMP-1), MMP-2, MMP-7 and MT1-MMP were remarkably elevated in Snail-1 compared with control transfectants.
We showed that SF reverses cartilage degradation processes and inhibits expressions of matrix metalloproteinase-1 and BAX in a rat OA model in vivo.
Huang et al. detected the expressions of matrix metalloproteinase 9 (MMP-9) in meningiomas to determine whether they are a valuable recurrence predictor for meningioma.
Furthermore, interaction with NF-25 fibroblasts not only induced the epithelial mesenchymal transition-like change, but also expressions of matrix metalloproteinase- related genes in HSC-39 cells.
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We further explored that the reduction of HDAC4 level led to a significant repression of proinflammation cytokines induced up-regulated expressions of matrix-degrading enzymes (MMP1 (Matrix metalloproteinase 1), MMP3 (Matrix metalloproteinase 3), MMP13 (Matrix metalloproteinase 13), ADAMTS4 (aggrecanase 1) and ADAMTS5 (aggrecanase 2)) in SW1353 in vitro.
Proinflammatory cytokine-induced expression of matrix metalloproteinases (MMPs) is a major cause of arthritic cartilage destruction.
Introduction: The expression of matrix metalloproteinases (MMP) is essential to the angiogenic response following tissue ischemia.
Over-expression of matrix metalloproteinases (MMPs) has been linked to a variety of serious pathological disorders.
Expression of matrix metalloproteinase-9 is deregulated in numerous wound healing pathologies.
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