The ideal is that of free thought and expression by which minds are formed and refined.
TFs facilitate bone-specific gene transcription and ultimately gene expression by which MSCs undergo differentiation and acquire the osteoblastic phenotype [22].
Thus, our study established a molecular basis for further understanding the mechanisms governing FTO gene expression, by which FTO may act as a regulator to enhance adipogenesis.
Our results identify a feedback loop in SMN expression by which low SMN protein levels exacerbate SMN exon 7 skipping, leading to a further reduction in SMN protein.
Ectopic expression of TIP30 in HCC cells enhances p53 expression and decreases Bcl-2/Bcl-xL expression by which TIP30 increased sensitivity of the cytotoxic drug 5-FU and prolonged survival of nude mice bearing subcutaneously established HCC tumours.
Indeed, the threshold of expression by which genes were assigned to the EB1 and EB2 datasets was arbitrary and the choice of this threshold could have inflated the entity of the tissue signature effect.
The strongly inducible promoters of the MOX and FMD genes are commonly used as regulatory components for enhanced heterologous gene expression, by which correspondingly high protein concentrations, up to 70% of total soluble cell protein content, are attained [ 11].
Deciphering and reconstructing gene transcriptional regulatory networks are important for better understanding the fundamental cellular processes, such as cell division, growth control and gene expression by which cells can adapt to environment more effectively [ 1].
For example, Clarkson and coworkers [ 2] note a general trend in gene expression by which death receptor pathway components are upregulated at the earliest time points studied, whereas proapoptotic and antiapoptotic components that influence the intrinsic mitochondrial contribution to apoptosis (such as Bax, Mcl1, Bcl2l, and Apaf1) are more highly expressed later in involution.
Potentially the evaluation of HER4 expression, by which valuable additional prognostic or even predictive information might possibly be revealed either from immunohistochemistry or FISH even without differentiating between HER4 splice variants, could contribute to therapy decisions and/or optimisation in the future.
