We know what Blake's life-mask looks like (it survives in the Fitzwilliam Museum, tense and resistant); Park imagines how Catherine bathed his face in warm water after the plaster was removed, bringing his expression back to life.
As a die hard Drag Race fan, I immediately death-dropped to the floor when I heard that RuPaul would be bringing DragCon a self-described celebration of "the art of drag, queer culture, and self expression"—back to Los Angeles for its third year.
Similarly, 46 genes in cluster-2 are underexpressed in ob/ob as compared to B6 and leptin treatment could correct the expression back to normal.
EL supplementation (ORX + EL) was able to increase the OPG gene expression back to SHAM level.
The upregulation of COMP gene expression back to primary fibrochondrocyte levels by the third passage was another exciting finding.
The ultimate goal of epigenetic therapy is to revert the transcriptome from a tumor-specific pattern of gene expression back to the expression patterns seen in normal cells.
Suppression of Myc expression back to its physiological levels results in tumor regression in a wide variety of cancers, including hematopoietic, epithelial, and mesenchymal tumors [ 7, 13– 16].
Presumably, in wild-type mice, hdc expression increases to combat the effects of sleep deprivation, and BMAL1 represses hdc gene expression back to baseline levels, ensuring good recovery sleep.
Concomitant with the resensitization to JAK2i, SET-2-TGRR and SET-2-RuxRR cells showed restoration of phospho-JAK2, -JAK1, -TYK2 and -STAT5, and Bcl-2 and Bcl-xL expression back to basal levels seen in SET-2-Veh cells.
In conclusion, our data are consistent with a gene dosage-dependent neurodegenerative effect of spastin in human SPG4 neurons and suggest that bringing wild-type spastin expression back to normal levels might halt neuronal degeneration in patients.
