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The names of genes belonging to the corresponding "Expression Wave" are included below the graph.
Moreover, Masai et al. (2005) found using forskolin, an activator of PKA, that Hh signalling during 22 26 hpf period is essential for ath5 expression wave, also highlighting the role of extraretinal Hh signalling for retinal patterning [36].
In brief, transcripts were included into a particular expression wave represented by a single artificial template, if its correlation with the specific pattern was higher than a certain threshold and also highest among all other patterns.
Similarly, a calcium wave [ 37], a gene expression wave [ 38], or other types of cell-to-cell interactions may be consistent with a rolling ball model.
The time scale of signal propagation, which is on the order of hours in butterfly development, is more consistent with a gene expression wave, although it would be possible for rapid repetitive electrical or calcium waves to induce a slow expression wave.
Two of the factors, sall4 and Fut1, displayed modest upregulation during tail blastema formation, but no statistically significant upregulation during limb regeneration even though both factors showed a similar expression wave over time in tail and limb regeneration.
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The inspector, with a bored expression, waved me through.
At one point, he uses the expression "waving the sole tyre".
Other manifestations of such collective behavior, arising from the functional relations between gene expressions, were observed in terms of coordinated genome-wide expression waves [30], [31].
To better illustrate and map co-regulated genes with different activation and deactivation profiles, the levels of every transcript have been assigned to graphs of "Expression Waves" that follow a particular, predetermined, expression pattern (Figure 5).
A Dex-on, Tet-off system has been described in plants [27], but in that case the administration of the inducer and the antagonist are simultaneous, and do not give rise to gene expression "waves" like the ones described here.
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