According to Delfortrie et al (2011), tumours with high EGFL7 expression are characterised by impaired blood vessel integrity, representing an obstacle to the delivery of chemotherapy to the tumour cells caused by a diminished pressure gradient, which is in accordance with the present results.
One expression profile was characterised by low expression of drug resistance proteins and high expression of proliferation/angiogenesis-regulating proteins (CIM areas M to O).
The miR-21 expression pattern was characterised by intense expression in the tumour area in contrast to the normal mucosa, where weakly stained mononuclear cells were observed.
The expression profile was characterised by upregulation at two time points; during early infection 4 wpi and at peak pathology 9 wpi.
The expression profile of BRCAX-C group was characterised by lower expression of Cluster 1 and Cluster 2 miRNAs and higher expression of Cluster 3 miRNAs compared with normal breast tissue, and highly resembled that of BRCA1/2 tumours.
Two groups of tumours with specific protein expression patterns were identified by RPPA: Group A was characterised by low expression of HSP90, HSP27 and p-HSP27(Ser78, Ser82, Ser82) and high expression of GRP78, GRP94, HSP70 and HSP60; Group B exhibited the inverse pattern.
Our results show that most (eight out of nine) synovial sarcomas clustered as a single group based on their gene expression portrait and that this cluster was characterised by the raised expression of a set of 48 genes.
In particular, when differential gene expression was compared between C and dwarfAO, the dwarfAO was characterised by increased expression of genes encoding glucosinolates, which are known precursors of phenethyl isothiocyanate, linked to the anti-carcinogenic effects well-documented in watercress.
The IBL was characterised by low expression of ?1 integrins and high expression of the β2 laminin chain.
Abnormal PMN-CD64 and MON-CD64 shared the same trend (upregulation) while abnormal monocyte MON-Ia was characterised by declining expression.
