These results are consistent with a previous report of Martel-Pelletier and colleagues showing that 5-LOX expression is activated after that of FLAP, leading to the late increase of LTB4 production [ 28].
NFkappa-B (NFκB), a key regulator of COX-2 expression, was activated 72 h after MA administration, and was accompanied by increased Ikappa B (IκB) phosphorylation.
In a previous study, we demonstrated that the SAG12 expression was activated in unfertilised pistils shortly after anthesis, decreased afterwards, and increased again at the end of pistil development, at around 10-12 DPA.
In the sham group, few SOX-2-positive cells co-expressed with RAGE were found. 2 weeks after SCI, SOX-2 expression was activated (SCI group vs sham group, 42.45 ± 10.04% vs 3.13 ± 2.66%, p < 0.001; Fig. 3a,b).
In these super-overexpression resistant lines, pathogenesis-related (PR) gene expression was activated.
IF showed that anti-RAGE treatment also suppressed nestin expression that was activated after injury, but most nestin cells co-expressed with MAP-2 were partly suppressed by RAGE blockade at 1 week after SCI (Figs 4 and 5), suggesting that RAGE may regulate NSC differentiation into mature neurons.
For example, previous work identified a cluster of seven genes whose expression is activated soon after birth (List C Elastic Fiber Genes from McLean et al. 2005).
These results suggest that the expression levels of LC3 were up-regulated and that autophagy was activated after rapamycin treatment.
