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Twenty-eight SNPs of them belong to the type Stop loss which may cause delay termination of gene expression or inability of the gene expression to terminate.
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Some of these will regulate downstream gene expression, whereas others are required to terminate immediate early gene expression (e.g. Atf3 operates in a negative-feedback loop with Egr1 [ 20]).
The OEE also binds repressors that are required to terminate expression in PMCs after 24 h ("PMC−" activity).
Virtual perturbations on feedback loops suggest that both positive and negative feedback loops are required to terminate expression of early meiotic proteins.
In combination with regulated promoter systems, therapeutic levels of a molecule are produced, so avoiding excess (toxicity) and inadequate (no effect) production, and this also provides a means by which to terminate expression in the event of adverse effects.
However, for clinical application regulated promoter systems are more flexible because they enable the level of expression to be controlled and provide a means by which to terminate gene expression.
Several important negative feedback mechanisms collaborate to terminate the expression of these genes several hours after IFN stimulation, for example, expression of the potent negative regulator SOCS1 is rapidly induced by IFN (Yoshimura et al, 2007).
Several important negative feedback mechanisms collaborate to terminate the expression of these genes several hours after IFN stimulation; for example, expression of the potent negative regulator SOCS1 is rapidly induced by IFNs [ 48].
Cells were grown in galactose medium to induce DSB formation, followed by transfer to glucose medium to terminate HO expression.
Indeed, the dpn gene contains consensus PROS binding sites [21] and PROS has been shown to be required to terminate the expression of dpn in the embryo [26].
Since more than 80% of cells have acquired a DSB after 60 min of galactose induction, we decided to terminate HO expression at 60 min by transferring the cell cultures into glucose medium to follow DSB repair.
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