Our findings that the MeCP2 forms mutated either in the MBD or TRD domains conserve their repressive effect on MHC class I expression strengthen this interpretation that MeCP2 has an indirect effect on transcription through its effect on chromatin architecture.
These observations are consistent with a recent report showing that CDK2 or CDK4/6 expression strengthens Rb-Pin1 interaction in glioblastoma multiforme cell lines.
The association between promoter methylation and reduced mRNA expression strengthens the biological relevance of MAL methylation and supports a putative role as tumour-suppressor gene.
Some people even took the viewpoint that maspin expression only strengthened in invasive breast cancer of high histological grade and maspin over expression means high risk of death for patients without lymphatic metastasis [ 28].
Real time RT-PCR analysis of uPA and uPAR mRNA expression further strengthened the semi-quantitative RT-PCR results.
Conversely, reducing Fyn expression levels strengthened the γδTCR signaling response, as evidenced by the decrease, albeit not significant, in the number of DP thymocytes and the significant decrease in γδTCR surface expression on DN γδ thymocytes from Fyn+/− γδTCR Tg mice.
In several quantiles, controlling for expression actually strengthened the relationship between number of interactions and evolutionary rate.
By mid- and late-tailbud stage, the signal of the Pax2/5/8a expression domains strengthened, and a new domain appeared in the rostral-most ectoderm of the trunk, probably labeling the first two cells fated to invaginate into the stomodeum and form the oral epithelium (see below; Figure 3A).
As shown in Figure 10, CPI-17 over-expression significantly strengthened and prolonged MLC activation to the levels higher than those at normal CPI-17 level and normal concentration of thrombin, histamine and VEGF respectively [ 85].
The comparative study across bilateria, which now includes a lophotrochozoan representative, further supports the idea that the urbilaterian Adh3 ancestor showed an intron-rich architecture and tissue-specific expression, and strengthens the view that widespread expression of Adh3 was a vertebrate innovation.
