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These alterations in gene expression span multiple pathogenic pathways, including amyloid β peptide (Aβ) processing, tau hyperphosphorylation, and inflammation, among others.
This vast expression span among different members within a family suggested the precise expression of miRNAs under certain conditions.
In summary, our study, together with a recent similar report by Korshunov et al. [ 12], indicate CNS-PNETs with C19MC amplification and/or LIN28 expression span various histologies but comprise a single molecular disease that warrant common therapeutic strategies.
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CapI-lox4 is the only Hox gene expressed in both thoracic and abdominal tagma, and whose expression spans the thoracic abdominal boundary.
Because CAXIV is expressed in astrocytes, Müller cells, and the retinal epithelial cells, its expression spans the entire thickness of the retina.
This approach also explains why some of the gene known to be highly expressed by the boar epididymis were not found in the list of markers; these genes were either expressed in two different clusters (ie testis and epididymis) or their high expression spanned over different adjacent clusters and then they were not retained as differential between the epididymal transcriptomic units.
Microarray studies showed that gene expression spanning a region of approximately 84 kb upstream of the mutated gene was downregulated.
(2) INHBA, the fourth most up-regulated gene across the patients, similarly shows strand-specific expression spanning its locus (Figure 3b).
Infection resulted in a virus dose-dependent luciferase expression spanning at least 2 orders of magnitude at early time points post infection (Fig. 6) and 3 4 orders of magnitude at later time points (data not shown).
The cells displayed variability in the FRET standard expression spanning two orders of magnitude.
The maximum RPKM value was 37,015, indicating a dynamic range of expression spanning 6 orders of magnitude.
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