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Thus there was a larger metabolic gene expression shift in the diaphragm than the sternohyoid.
Indeed, the transcriptomic endometrial gene expression shift in the normal serum [P] group was comparable to the one previously described for patients in COS protocols [ 29].
For this purpose, Fisher's method was applied to p-values generated from one-sided hypothesis tests, where the P i and P j correspond to specific tests for an expression shift in a particular direction (up or down).
Therefore, in addition to cis-regulatory changes that led to a heterochronic CYC2 gene expression shift in the Brassicaceae, promoting corolla monosymmetry evolution [ 10, 12], also a divergence of trans-acting CYC2 proteins likely contributed to the establishment of this morphological novelty.
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Gene expression shifts in both human psoriasis and mouse psoriasiform phenotypes are, in part, a consequence of KC responses to the local cytokine and chemokine environment.
Individuals of many vertebrate species show different stress coping styles and these have a striking influence on how gene expression shifts in response to a variety of challenges.
As an alternative analysis method, we also extracted sets of human-mouse gene pairs with correspondent expression shifts in mouse phenotypes and human psoriasis, and identified GO biological process terms overrepresented within these gene sets.
Subsequent bioinformatic analysis showed that most DEGPs exhibit similar mRNA expression shifts in other skin diseases.
Expression shifts in psoriasis lesions may be associated with disruption of homeostasis or cutaneous inflammation, which is characteristic of many skin conditions [ 6, 60, 72, 73].
For example, Sandberg et al. [ 4] have found that just 13%% (101/804) of parallel gene expression shifts in their thermal stress experiment are reinforcements, a classification that can be considered a type of novelty in their system.
We further confirmed our previous finding on species/lineage-specific gene expression shifts in the sex steroid pathway, including synthesizing enzymes as the aromatase cyp19a1 and estrogen and androgen receptors.
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