"The magnitude of the gene expression response really floored us," Castoe says.
What these data are revealing is the full complexity of the gene expression response to stimuli such as xenobiotic exposure.
The aim of this study was to investigate the global gene expression response of normal tissues following internal low absorbed dose irradiation of 131I.
These graphs represent the average signal intensity of the gene expression response of 3 volunteers with the error bars reflecting the standard deviation among the 3 individuals.
This gene regulation circuit yields a bimodal expression response.
A synthetic positive feedback system resulting in binary expression response was transduced via lentiviral transduction.
We observed that the gene expression response to IH or CH is specific and paradigm-dependent.
Nevertheless, specific differences in the gene expression response to these two diets do exist.
In that sense, SKN-1 is known to mediate an expression response of genes involved in phase II of detoxification.
In conclusion, our study shows that there is a shared in vivo expression response to different inducers of lung inflammation.
In total, 1229 proteins met these criteria for a significant change in expression response to the imposed copper treatments.
