However, this approach requires doubly transfected cells, whereby β-gal (lacZ expression) releases luciferin, which becomes a substrate for luciferase.
Other cytoprotective molecules such as adenosine may therefore contribute, as HUVEC exposed to hypoxia and statins upregulate CD73 expression, releasing adenosine [ 22], which can induce NO synthesis.
It is thus reasonable to propose that the MSU-induced downregulation of MICL expression releases the inhibitory activity of this receptor in neutrophils permitting the activation of the neutrophil by this nonmicrobial agent.
To investigate the expression, release, and proteolytic degradation of galectin-3 in patients with dry eye disease.
Our in vitro assays confirmed the expression, release and selective killing effect of the immunotoxin produced by hMSCs.
During his time in the hospital, Meyer turned to art as a means of expression, release and inner healing.
The aim of our study is to test an ex vivo coculture model that will allow monitoring of the expression, release and regulation of paracrine factors during interactions of an intact femur explant and tumor cells.
Owing to the BH3 domain possessed by Beclin1, both Bnip3L and Bnip3 compete with Beclin 1 for binding to Bcl2, which upon their increased expression releases Beclin 1, causing induction of autophagy.
Most importantly, a simultaneous decrease in Pax5 gene expression releases IgH, Igκ, and J chain from repression, leading to enhanced production and secretion of immunoglobulin by plasma cells [ 28, 29].
Compared to rotenone-treated control cells, overexpression of WT ALDH2 significantly blocked rotenone-induced Bax expression, release of cytochrome c, activation of caspase-9 and caspase-3 (Fig. 4B).
