Only direct interactions--direct regulation of gene expression, protein-protein binding, or promoter binding--were used.
The expression the protein binding partners of DcR3 and their native ligands (Fas, FasL, LIGHT, LTβR, HVEM, DR3, and TL1A) was determined by flow cytometry.
The GTC team offers sample-to-data solutions for gene expression, protein-DNA binding (ChIP) analysis, microRNA expression, and more.
Cytosine methylation is an epigenetic regulatory mechanism that is able to control gene expression by inhibiting protein binding to DNA and by changing chromatin structure [23].
We have characterised the expression profile and protein binding partners of the two homologous, functionally uncharacterised proteins, hAG-2 and hAG-3.
We show that therapeutic drugs are able to disrupt the YY1 gene expression and YY1 protein binding to FEN1 promoter region.
One other explanation is that a percentage of tumors with ARTN expression may not functionally respond to ARTN due to lack of expression of proteins binding ARTN.
Non-histone acetylation plays a role in protein stability, DNA binding, gene expression, protein interactions, localization, mRNA stability, and enzymatic activity26.
Recently emerged deep sequencing technologies offer new high-throughput methods to quantify gene expression, epigenetic modifications and DNA-protein binding.
Different strategies to target hypoxic cancer cells and/or HIFs include hypoxia-activated prodrugs and inhibition of HIF dimerization, mRNA or protein expression, DNA binding capacity, and transcriptional activity.
