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While not selected relative to specific disease or expression outcome, fitSNPs represent a set of markers enriched for functionally relevant variants (e.g. non-synonymous coding region polymorphisms) from across the genome.
Major limitations to studying GPCRs include the difficulties in using high-level heterologous expression platforms (being baculoviral-mediated and transient mammalian expression the most commonly used) and the unpredictability of the expression outcome.
Further, single-gene expression outcome prediction is limited for cancer evaluation since genes do not act in isolation, but rather interact with other genes in complex signaling or regulatory networks.
It is possible that oncogenic stress induces an up-regulation of both RARγ and Suz12, promoting an aberrant association between the two proteins leading to abnormal RARγ function and gene expression outcome.
Analysis of gene expression networks provided evidence that the parasite establishes tight control over pathways associated with cellular activation by modulating reception of extrinsic stimuli and by significantly altering the expression outcome of genes targeted by infection-activated transcription factors.
Derivation of the eight profiles of genes displaying altered expression levels in infected TBL20 cells relative to LPS-stimulated uninfected BL20, provides evidence that T. annulata-infected cells alter the gene expression outcome associated with an activation event, i.e. the response to LPS.
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Writing instruction effects on various written expression outcomes were aggregated by averaging percentage of non-overlapping data (PND) across studies.
Here, 1) we provide a historical perspective on advances in H. jecorina molecular biology, 2) outline host strain engineering, transformation, selection, and expression strategies, 3) detail potential pitfalls when working with this organism, and 4) provide consolidated examples of successful cellulase expression outcomes from our laboratory.
The differential expression outcomes were further substantiated by FDR.
We finally examined the gene expression outcomes following cytokine stimulation (OSM 3 h).
As these examples show, modulation of DNA methylation by PARP-1 can impact the genome and affect gene expression outcomes.
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