CDF1 in turn controls CO expression depending on time of day [ 44].
DEGs were clustered in six groups according to their expression profile on time (Fig. 4 and Additional file 11).
A univariate two-sample T-test with significance threshold of p<1×10−3 in BRB-ArrayTools was further used to determine significant gene lists of gene probe sets differentially expression on each time point (day 1, 3, 7, 10, 14, 28, and 56 vs. day 0 intact control) post-ablation.
The impact of Kv10.1 expression on survival time was evaluated using the Cox hazards regression analysis.
Additionally, adding the kif21b risk SNP to the Hazard regression model for the effect of abundant kif21b expression on the time to develop EDSS 6.0 did not alter the results, indicating that kif21b expression is the explanatory factor (Additional file 1: Table S5).
In order to analyze the contribution of each pox gene to the total relative expression on the time-course fermentation, their transcriptional levels were also shown as percentage of the total expression (Fig. 4).
In order to decipher the mode of Rage function on gene transcription levels during inflammation, we applied global gene expression profiling on time-resolved samples of mouse back skin, which had been treated with the phorbol ester TPA, a potent inducer of skin inflammation.
Our findings demonstrate that drought responsive gene expression depends strongly on time of day and that gene expression is extensively modified during the first few hours of drought recovery.
