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Our results help to resolve the apparently conflicting reports by demonstrating that the effects of increased dSir2 expression on life span in Drosophila are dependent upon dSir2 dosage.
The extension of life span seen when dSir2 expression is moderately increased led to the hypothesis that there may be a dose-dependent element to the effect of dSir2 expression on life span.
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That old expression "flaming youth" took on life again.
We hope to reach a truly global expression of life on earth - nuanced, diverse, beautiful and ugly, thrilling and terrifying, touching and rude, serious and absurd, frank, honest, human".
These results demonstrate a dose-dependent response for increased dSir2 expression on fly life span, even for transgenic constructs previously reported not to extend life span.
It is the dynamic expression of life.
It is an expression of life, and of being alive.
The effect of p53 deletion, mutation, and over-expression on Drosophila life span was assayed in multiple trials for several lines.
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In order to examine whether increased dSir2 expression might have a dose-dependent effect on life span, we plotted dSir2 expression levels and life span extension from both our studies and those of published life spans (Fig. 2A and B).
Model for the effects of neuronal activity on H2BE expression level, life span and resulting neuronal representation.
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