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Moreover, expression of the reduced cleavage PINK1-P95A mutant, in the absence of any uncoupling agents, was consistently observed to reduce the basal Δψm significantly and induce a reduction in mitochondrial mass.
In the present study, we demonstrated for the first time that the expression of the reduced folate transporter SLC19A1, which is important for MTX uptake into cells, is strongly related to the efficacy of MTX in an arthritis model.
Gene-expression analysis revealed prominent expression of the folate receptor in some but not all mesothelioma cell lines, and in only one case was expression of this receptor gene greater than expression of the reduced folate carrier gene.
High expression of the reduced proliferation signature correlated with poor survival in all patient groups.
Xenografts were assigned to either the low- or high-proliferation group based on expression of the reduced proliferation signature.
Figure 1A shows that expression of the reduced proliferation signature was significantly lower upon serum starvation compared with control growing conditions (P=1.52 × 10−11, t-test).
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For three remaining cases, the explicit secular equations are derived from the secular equation for the compressible/compressible case by using the incompressible limit technique along with the expressions of the reduced elastic compliances in terms of the elastic stiffnesses.
The expressions of the reduced stiffness elastic coefficients, as well as the transformed ones, are given in literature (Reddy 2004).
In further support of Nrf2 regulating a STING-dependent antiviral response we observed that in HEK293 cells stably expressing STING the expression of Nrf2 reduced the IFN-response to known STING agonists, including HSV-1 (Supplementary Fig. 5b d).
In vivo electroporation studies also revealed that the ectopic expression of Pou3f1 reduced the expression of the BMP target gene cId1 (6/10) at the edge of the chick anterior peripheral ectoderm, whereas the control vector did not (0/11).
Curiously, reduced levels of Nipped-B reduced expression of the cut gene (a homeobox protein important in morphogenesis), while reduced SMC1 increased its expression [25], [59], [60].
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