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These data suggest that mesenchymal-like gene expression of the pit cell in both mice and humans is induced by Hh signal activation.
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Moreover, deficiencies are specific to a subset of endocrine cells, those secreting GH, PRL and TSH, which belong to the same lineage defined by expression of the transcription factor Pit-1.
Sonic hedgehog has previously been reported to be absent in pit cells in one study (van den Brink et al, 2001), whereas another study detected Shh expression in the pit region of Mongolian gerbils by in situ hybridisation (Suzuki et al, 2005).
The expression of Shh in the pit may differ between FVB mice utilised in this study and mouse strains utilised in other studies (van den Brink et al, 2001; Fukaya et al, 2006).
The expression of Pit-1 is over fourfold higher in PASC1 than in the daughter cells.
Our results also show a high concordance in the expression of Pit-1 and PRL.
This suggests that depending on its level, the expression of Pit-1 may be involved in normal mammary development, breast disorders, or both (Gil-Puig et al. 2005).
Using CD4+ autoimmune Teff cells, we demonstrate that peptide immunotherapy (PIT) is strictly dependent upon sustained T cell expression of the co-inhibitory molecule PD-1.
In 1951, Phelps Dodge mining company began the Lavender Pit, a new open-pit mine, but in 1967, the company began to predict the close of the Pit.
(a) Near the rim of the pit.
(c) At the center of the pit.
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