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The question whether iPSC derivatives are immnogeneic or not is straight forward; however, the answer to this question is very complicated due to the developmental randomness of iPSC and the nondeterminacy of the abnormal expression of the minor antigens.
Expression of the minor virion structural protein VP2 of the calicivirus murine norovirus (MNV) is believed to occur by the unusual mechanism of termination codon-dependent reinitiation of translation.
The low expression of the minor form may have precluded its detection by SDS-PAGE.
Furthermore, our screen revealed that expression of the minor variant KKv2 was restricted to only RCCs with highest KKv1 expression (18 of 169 (11%)).
Our data show that it is possible to modulate the mRNA expression of the minor frataxin isoforms and that they may have a functional role.
As expected, the expression of the minor catalase/peroxidase encoding gene katA (BCAM2107) was not altered in response to exogenous oxidative stress [ 12].
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As P. gingivalis fimbriae play critical roles in colonization and binding to other biofilm species (reviewed in11) we analyzed the level of expression of both the (minor) mfa-1 and (major) fimA fimbriae by P. gingivalis grown alone, in two-species (incomplete) and three-species (complete) consortia in vitro.
Within a gene, isoform ratio of the AS event was set as the expression level of the minor transcript divided by that of the most abundant transcript.
Algorithms and queries were developed for searching the dbMinor, for screening the expression of the immunogenic minor H antigenic allele(s) in an HLA-typed individual, and for screening HLA-typed and minor H antigen-typed donor/recipient pairs for putative immune reactivities in the specified combination.
Is it really necessary to "give someone the finger" as an expression of the most minor of annoyances?
Expression of the two minor transcripts, c and d, was also associated with the rs4072037 allele.
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