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We therefore examined, in the three validation datasets, the expression of the ERA genes that were regulated by MYC in MCF7 cells (Figure 3).
First of all, the expression of the era gene used for complementation is not regulated by its native promoter.
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To him we owe many of the signature expressions of the era, among them "Mayberry Machiavellis" (from his essential and prescient 2003 Esquire piece on Karl Rove and John DiIulio, first chief of President Bush's "faith-based initiative") and "reality-based community" (from an October 2004 article for The New York Times Magazine).
Our study demonstrates antagonistic regulatory effects of HNRNPG and HTRA2-BETA1 on ERa exon7 splicing with potential impact on type 1 EC clinical outcome due to the consecutively variable expression levels of the ERa isoform D7.
"The cinematic style of late Mikhalkov is an extremely faithful expression of the Putin era, in which polemics are also senseless," he wrote in the April 21 edition of the newspaper, and offered a series of possible interpretations for qualities they both share: "Extreme cynicism and the domination of personal proximity to the source of power above all other criteria?
Yet his fourth, fifth and sixth symphonies, written between 1931 and 1947, are as important a vernacular musical expression of that era as anything one can think of.
The colossal white stone "column of fame," with its golden cupola gleaming above the Kremlin hill, was the definite expression of an era, reflecting the tastes and grandiose political ambitions of the rising Russian state.
Today's emphasis on gender identity has its roots in the sexual expression of the "Alone at Last" era.
However, triple-negative (TN) cancer is phenotypically defined by the lack of expression of ERA, PR and the absence of HER2 overexpression and amplification.
Shand is brought down, of course, by the great conundrum of the Thatcher era: the Northern Ireland troubles; that fantastic final shot, a full two minutes of Hoskins' appalled expression, sums up the hubris of the era almost before it began.
With the samples forced to order first by ER status and then by ERBB2 level we examined the differential patterns of expression of the Musgrove_Myc_U+D subset of the ERA genes relative to molecular subtype and the ability of this gene set to distinguish directly- and indirectly-regulated E2 and MYC targets.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com