Most interestingly, it was additionally shown in several animal studies that changes in the mRNA expression are one of the consequences of adverse maternal care.
It is possible that either through abrogation of the effect of E7 or as a result of epigenetic or mutational silencing of host p16 (O'Regan et al, 2008), the HPV+ve/p16−ve tumours lack the molecular consequences of E7 expression and that one of the consequences of this is lower radiosensitivity compared with HPV+ve/p16+ve tumours.
But at a higher level of analysis, we still do not understand the genetic architecture of gene expression in brain, the consequences of expression QTLs on protein levels or on cell function, or the combined impact of expression differences on behavior and disease risk.
Our data indicates that increase of SPL expression in AD could be one of the consequences of Aβ accumulation.
The Congress, while it has a right to express its opinions on critical issues of the day, also must be cognizant of the consequences of the expressions of those opinions".
Given the ever-increasing use of thy1-XFP mice for not only cellular, but also molecular, experiments in the healthy and pathological nervous system, a thorough investigation of the consequences of XFP expression in neurons of these mice is required.
One of the consequences of ectopic expression of CTDSP2 is a strong reduction of the number of S-phase cells.
Investigations of this type will facilitate a better understanding of the consequences of altering expression levels of genes that function in important biological pathways.
In systems biology and the study of gene expression [ 1- 3], the consequences of stochasticity can manifest in numerous ways such as slow promoter kinetics leading to gene transcription bursting [ 4, 5], finite-number effects and mRNA translation bursting [ 6- 9], propagation of noise in gene regulatory cascades [ 4, 10], and phenotypic switching [ 11, 12].
For these reasons, we were more interested in pursuing the knockdown of LKB1 in our ccRCC cell lines to recapitulate the clinical observation of decreased LKB1 expression and investigate the consequences of decreased LKB1 in ccRCC.
