Our laboratory has developed a custom approach to this technology, designing cDNA microarray platforms specifically for gene expression events of relevance to a large number of toxicological endpoints.
In order to identify gene expression changes of relevance for early bladder transformation, the transcriptional profiles of 25 primary Ta tumours from bladder cancer patients were compared with those of nine normal bladder biopsies from patients with no bladder cancer history.
The inverse correlation between miR-93 levels and VEGF and IL-8 expression is of relevance, as shown in Fig. 3, since these two genes might be under the post-transcriptional control of miR-93, as recently proposed in different experimental model systems [ 21, 29, 35].
Secondly, expressions (sentences/paragraphs) of relevance to the study aim were identified and divided into meaning units.
As the prognostic value for TWIST1 mRNA expression is confined to ER-positive breast cancer, we assessed whether ER expression might be of relevance for TWIST1 mRNA expression in tumor tissues with a variable amount of stromal content.
The involvement of Egr-1 in IL-1-mediated downregulation of PPARγ expression may be of relevance for other stimuli known to modulate PPARγ expression.
