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To evaluate the differential expression of preferred miRNAs between normal and breast cancer cells we performed miRNA body map analysis (http://www.mirnabodymap.org/) based on database instructions [ 24].
The heat map based on color (blue: down regulation and red: up regulation) and cluster clearly depicts the differential expression of preferred miRNAs between normal and tumor breast cells.
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(E ) Relation between age fold change (ln(P8/P60)) of the expression of the preferred (PA) and the non-preferred allele (Non-PA) of imprinted genes.
First column: distribution of preferred positions.
I think the authors should at the very least motivate more persuasively why the more exotic hypothesis of chaotic gene expression is preferred over the established picture of multistable switches.
TRAK1 exon 1A was found to be expressed in only two normal epithelial samples, whereas no expression of the tumor preferred exon 1B was observed in either fraction from the normal sample.
This method of calculating gene expression was preferred over normalization to a housekeeping gene, because such genes are not constant under the broad range developmental and nutritional conditions of our experimental protocols.
17 As adolescence is a time of increasing independence and adoption of new behaviours, we regarded screen time spent during weekends (ScTWends) as the best expression of the participants preferred pastime with a plausible effect on health.
On the other hand, the long time females spent with the decoy exhibiting the intermediate expression of the trait preferred in the binary test suggests that females may be limited in discriminating the trait magnitude.
The absolute preference values, for both 'size ' and 'yellow ' females, were influenced by the relevant amount of time spent by females in inspecting the decoy that showed an intermediate expression of the trait preferred in binary test (size females: 38%% of time with focal S and 35 % with Ds; yellow females: 48 % of time with focal Y and 27 % with Dy).
This has become a familiar conceit in recent years: we defend the right of freedom of expression but prefer not to exercise it in situations that might endanger us.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com