In the current study, supportive evidence for differential expression of genes participating in similar pathways in peripheral blood (e.g. FLT1) in early pregnancy is presented.
Thus, our approach of evaluating the sum of expression of genes participating in a category of interest is a crude, but necessary, first step in interpreting our expression results.
Consistent with our analysis of individual genes, the net changes in expression of genes participating in the BP categories indicates that the most active period of change in the transcriptome occurred during the last interval (from 40 to 60 DAA).
In summary, expression of genes participating in amino acid transport and metabolism were induced by ethanol, whereas the ethanol down-regulated genes primarily belonged to the categories of translation, ribosomal structure and biogenesis.
To determine whether Fam40b levels affect the expression of genes participating in differentiation/developmental processes, the transcriptomes of both control and 12-day KD EBs were profiled and compared with the transcriptome of undifferentiated WT ESCs.
Severe stress in protoplasts could be detected by the increased expression of genes participating in protection from reactive oxygen species (ROS), such as Pp1s424_33V6, thylakoidal ascorbate peroxidase; Pp1s26_74V6, glutathione S-transferase PHI 9, and others.
In addition, the expression of genes involved in energy metabolism, such as thioredoxin-like 4B, 5-oxoprolyl-peptidase, etc., were markedly down-regulated in fat line chickens, and the expression of genes participating in gluconeogenesis or glycolysis, including glycerol kinase (GK), ATPase, beta 1,3-galactosyltransferase etc. were up-regulated in this line.
This study shows that the expression of genes participating in DNA repair and replication are mostly up-regulated in NSCLC, as would be expected for proliferating cells, without indications for a severe dysfunction of these two cellular functions at the mRNA level.
