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The LCR perturbed expression of few genes in a 300 kilobase (kb) proviral vicinity but no upregulation of genes associated with cancer, including an erythroid-specific transcription factor occurred.
This effort can provide to develop antibody assays for the diagnosis of specific types of cancer and to provide accurate diagnostics by only measuring expression of few genes.
The expression of few genes was modified in transgenic poplar plants overexpressing the cytokinin-response regulator PtRR13, in which AR formation was inhibited [ 14].
The present work shows that the expression of few genes was considerably changed after M. bovis infection, irrespectively of the strain used to infect the macrophages.
Besides, among the 64 genes we selected for involvement in oncogenesis, expression of few genes (3 and 5 genes up or downregulated, respectively) are modified in cancer cells within colospheres vs within parental xenograft tissues.
Recently, Yona et al. (2012) have proposed that large copy-number variants are first acquired during the course of an evolution experiment and are rapidly replaced by a more refined adaptive solution (e.g., elevated expression of few genes).
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Low-dose (10 mg/kg/day) methapyrilene administration resulted in the differential expression of fewer genes in the liver, with the greatest number of differentially expressed genes observed after only one dose (715 genes).
The expression of fewer genes was repressed in Mtb following THZ treatment (Table 1).
The response of Mutyh−/− mice to a chronic DSS exposure is more restricted with altered expression of fewer genes in both categories.
These results show that PVYO-resistant Premier Russet responds to PVYO inoculation by changing the expression of fewer genes than PVY-susceptible Russet Burbank, in particular at 4 hpi, and that the great majority of these genes are DE in a variety-specific manner.
However, the expression patterns of few gene pairs, including PtSPL12/13 in G1, and PtSPL14/15 belonging to G2 are distinct.
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