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Several pioneering studies showed that ectopic expression of existing proteins or their elements can restore functions destroyed by mutations or normalize the signaling pushed out of balance by disease and/or current small molecule based therapy.
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To identify the universal expression pattern of existing protein spots on gel, densitometry analysis was employed.
Another potential explanation for the observed cortical differences in iOPN expression lies in the varying abundance of existing proteins in each cortex.
Most importantly, this response may extend beyond the duration of vector-mediated transgene expression and improve the efficacy of existing protein replacement therapy by preventing the induction of neutralizing antibodies, which represent one of the major hurdles of this treatment.
The reliability and coverage of existing protein-protein interaction data sets are quite different.
That is, they provide not just an example of co-option but of gene sharing, such that only comparatively minor changes such as in the amount and location of gene expression of existing proteins was required to produce the first simple layers of tissue capable of refracting light (Piatigorsky 2007, 2008).
Indeed, 50% of genes without existing protein abundance values have reported steady-state mRNA expression levels of less than 0.01 copies per cell.
The results of these analyses were compared with existing protein expression data for T. cruzi to determine the correlation, if any, between transcript and protein relative abundances in this human pathogen.
However, this exploration is an expression and critique of existing cultural roles for men and women.
Two of the existing proteins were upregulated and four proteins were downregulated post-infection (Figure 3).
Taken together, these studies suggest that phosphorylation of existing AP-1 protein subunits contributes to modulation of AP-1 transcription factor activity following specific ablation or rescue of EpCAM expression and/or signaling.
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