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Therefore, it is more likely that hibernation results from the differential expression of existing genes that have widely and long existed among mammals [ 8, 12].
Several pioneering studies showed that ectopic expression of existing proteins or their elements can restore functions destroyed by mutations or normalize the signaling pushed out of balance by disease and/or current small molecule based therapy.
That is, they provide not just an example of co-option but of gene sharing, such that only comparatively minor changes such as in the amount and location of gene expression of existing proteins was required to produce the first simple layers of tissue capable of refracting light (Piatigorsky 2007, 2008).
Mammalian hibernation is thought to be based on similar physiological mechanisms [41], [42] and a consequence of alternative regulation of general physiological programmes by the differential expression of existing genes.
Instead, it appears that the symbiosis is maintained by altering expression of existing genes involved in vital cellular processes.
On the contrary, it appears that the maintenance of the symbiosis is modulated by the alteration of expression of existing genes involved in vital cellular processes.
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In this study, we hypothesized that the adaptation of D. sechellia to the new host was achieved by changing expression levels of existing genes, and we expected enrichment of differentially expressed chemosensory genes in the D. sechellia lineage.
To identify the universal expression pattern of existing protein spots on gel, densitometry analysis was employed.
Rather, changes in the expression patterns of existing genes are important for phenotypic evolution [ 65- 68].
However, anatomical differences between vertebrate nervous systems can be sufficiently explained by changes in developmental expression patterns of existing regulatory and structural genes of the neuron.
Cells are able to respond rapidly to the changes of the surrounding environment, modifying the expression profile of existing mRNAs and controlling the rate of ribosome biogenesis at any given time through multiple regulatory mechanisms.
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