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HC11 cells constitutively expressing s80HER4 exhibited basal expression of differentiation markers, increased basal STAT5A activity and three-dimensional lumen formation.
Moreover, an altered proliferation and expression of differentiation markers induced by TNF-α were also counteracted.
Spheroids cultured in undifferentiated spheroids of 3 and 10 days retained expression of CD44, without expression of differentiation markers.
Not surprisingly, the results showed that the KD of HAIs caused a decrease in the expression of pluripotent genes while increasing the expression of differentiation genes (Fig. 2B).
In contrast, 1,25D failed to increase the expression of differentiation markers in blast cells isolated from patients carrying activating mutations in Flt3 gene.
A skin analysis of young animals revealed normal architecture and thickness as well as proper expression of differentiation and proliferation markers.
SRF-null skin exhibited abnormal morphology, hyperplasia, aberrant expression of differentiation markers and transcriptional regulators, anomalous actin organization, enhanced inflammation, and retarded hair follicle (HF) development.
Expression of differentiation markers was then analyzed.
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By promoting Ret phosphorylation in a GDNF-independent manner, the BDNF-stimulated TrkB, causes the induction of the neurite outgrowth and expression of differentiation-specific molecular markers.
Nevertheless, both studies indicate that HPV16 modulates expression of differentiation-associated genes.
HU-induced changes in the expression of differentiation-associated genes have been reported in studies on whole bone tissue [ 5].
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