Sentence examples for expression of defective from inspiring English sources

This growth defect can be overcome and cellular transformation promoted by the expression of defective, dominant negative alleles of p53 and of the mitotic checkpoint gene Bub1, both of which are known to induce chromosome instability.

Additionally, the expression of defective proviruses will need to be considered in the measurement of HIV-1 latency reversal.

As such, our understanding of the mechanisms that underlie the physiological and pathophysiological development of the human heart is mostly extrapolated from studies of the mouse and other animal models or heterologus expression of defective gene product(s) in non-human cells.

In contrast, several other studies reported that expression of defective CFTR or knockdown of CFTR protects against apoptosis phenotype [24] [29].

Absence of catalase in a cell would have a similar functional effect as expression of defective catalase.

In other systems, expression of defective myosins lacking a functional motor domain results in cessation of movement of the normal cargo carried by the particular myosin, a dominant negative phenotype [ 27].

In the proband's fibroblasts, we provided evidence for the lack of expression of the defective allele in vivo.

Moreover, expression of GTPase defective Gαs caused a prolonged duration of spike activity when compared to wt flies.

Therefore, chaperones and proteasome inhibitors may be clinically useful for restoring cell surface expression of "transport –defective or -processing" mutant proteins.

Recording the spike rates upon application of ethyl acetate to the ab1 sensillum revealed that expression of GTPase defective Gαs caused a prolonged duration of the spike activity compared to the control flies (Figure 3A).

Yao and Carlson agree to a large extend to our finding that odor evoked initial spike rates of ab1A, ab2A, and ab3A were not altered by expression of GTPase defective Gαs [30].