Sentence examples for expression of clearance from inspiring English sources

In vitro hepatic model systems comprising two-dimensional static monocultures of primary or immortalized hepatocytes are limited by their inability to maintain histotypic and phenotypic cellular characteristics over time in culture, especially stable expression of clearance and bioactivation pathways.

Generally, conventional in vitro hepatic model systems (i.e. 2-D static monocultures of primary or immortalized hepatocytes) are limited by their inability to maintain histotypic and phenotypic characteristics over time in culture, including stable expression of clearance and bioactivation pathways, as well as complex adaptive responses to chemical exposure.

Ultimately, this effort may promote wider use of formal urea modeling and facilitate research that requires measurement of hemodialysis or hemodialysis adequacy, especially involving the newer expressions of continuous equivalent clearance, and expressions of clearance normalized to body surface area.

Interestingly in contrast to HUVEC, the gene expression of ROS clearance enzymes, SOD1, GPX1, TXNRD1, TXNRD2, and PRDX1 were upregulated in HMVEC under hyperglycemia.

Treatment of 5xFAD mice, which have robust and early development of AD-like neuropathology, with a combination of L-DOPS and the NET inhibitor, atomoxetine, elevated brain NE levels, increased expression of Aβ clearance enzymes and brain-derived neurotrophic factor, reduced inflammatory changes and Aβ burden, and improved spatial memory [ 59].

As mentioned above, treatment of 5xFAD transgenic mice (which accumulate amyloid burden at early ages) with a combination of L-DOPS and atomoxetine elevated brain NE levels, increased expression of Aβ clearance enzymes and brain-derived neurotrophic factor, reduced inflammatory changes and Aβ burden, and improved spatial memory [ 59].

Further mechanistic studies demonstrated oleocanthal to increase the expression of important amyloid clearance proteins at the BBB including P-glycoprotein and LRP1, and to activate the ApoE-dependent amyloid clearance pathway in the mice brains.

To summarize, down-regulation of ENGASE expression delays clearance of fOSGN2 from cells.

Expression of mRNA for clearance receptors (macrophage receptor with collagenous structure and macrophage scavenger receptor) was enhanced in the livers of CSF1-Fc treated animals, assoCSF1-Fc treatedincreanimalsthe phassociatedapacity of the liver detected using injected microbeads.

Signaling via IFN results in suppression of viral gene expression and clearance of infected cells by leukocytes [64]– [67].

This study provides important insights to how DNA delivery by intradermal electrovaccination affects the local immunological responses of the skin, transgene expression and clearance of the plasmid.