Sentence examples for expression of checkpoint from inspiring English sources

Therefore, it is plausible to integrate both tumor and immune cell profiling with molecular data from the expression of checkpoint molecules and mutational burden to create the predictive assessments for patient selection, which may lead to an improved outcomes from immune checkpoint blockade therapy and pave the way for precision medicine to surmount NSCLC using these novel agents.

Genes encoding checkpoint components are very infrequently mutated (reviewed in [2], [5]) and, although reported in some instances, altered expression of checkpoint proteins or mRNA does not appear to correlate well with the status of CIN (e.g. [6] [8]).

The presence of effector cells in conjunction with the expression of checkpoint molecules suggests that the ccrcc4 molecular subgroup could be enriched for responders to inhibitors of the PD-1 pathway.

This subgroup also had the highest expression of checkpoint molecules, such as PD-L1 and PD-L2, among all CRC subgroups studied, which suggests it could respond to anti-PD-1 treatments [ 7].

Importantly, we found that HDACi alter cell cycle progression by decreasing the expression of G2 checkpoint kinases Wee1 and checkpoint kinase 1 (Chk1).

Spindle checkpoint proteins are essential for survival in mammalian cells (10- 12), thus researchers have used either cancer cells with weakened checkpoint function or cultured cells with conditional expression of mutant checkpoint proteins or siRNA to investigate the correlation.

The resulting increase in cytokine signaling enhances the expression of immune checkpoint targets, including PD-L1, thereby making the tumor more susceptible to checkpoint inhibition therapy.

30, 32, 33 Expression of immune checkpoint molecules: CTLA-4 and PD-L1 are highly expressed on Treg cells and tumor cells, respectively.

Elevated expression of mitotic checkpoint genes has been associated with chromosomal instability in breast cancer cells [ 40, 41], and the mitotic checkpoint module genes showed a considerable overlap with a signature for chromosome instability in tumors [ 42].

Zhou, X. M. et al. Intrinsic expression of immune checkpoint molecule TIGIT could help tumor growth in vivo by suppressing the function of NK and CD8 T Cells.

Predictive markers may include epidemiological factors such as ethnicity, the genomic status of the tumour, circulating markers, expression of immune checkpoint molecules, and other features of the stromal/immune response at the site of the tumour.